Glutathione Nasal Spray is generally well tolerated
Acknowledgements This work is supported by the Junior Group Leader program of the Rudolf Virchow Center, University of Wrzburg and Deutsche Forschungsgemeinschaft (DFG) FR 3746/3-1 to J.P.F.A., the DFG CO 291/5-2 and CO 291/7-1, the German Federal Ministry of Education and Research (BMBF) through the Joint Project Modelling ALS Disease In vitro (MAIV, 01EK1611B) and the VIP+ program NEUROPROTEKT (03VP04260), as well as the m 4 Award provided by the Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi) to M.C., the Cancer Research UK (CRUK, grants C29637/A20183 and C29637/A21451) to E.W.T., the European Research Council (LipidArrays) to V.O., the Natural Sciences and Engineering Council of Canada and the Canada Foundation for Innovation to D.A.P
Highlights glutathione among several agents that can shift melanogenesis toward pheomelanin synthesis, offering insight into alternative hyperpigmentation therapies
Besides eNOS uncoupling, inhibition of the enzyme may also result in a significant drop in vascular NO levels, resulting in endothelial dysfunction and alterations in vascular tone, which may lead to hypertension
